How can small molecule degrade?

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How can small molecule degrade?

Postby talkingtree » Sep 03 2018 2:42 am

Hi,

Very basic general question for human studies. For proteins, it degrades due to protease during circulation. And what is causing small molecules to degrade in blood? A protein, another molecule, cell?
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Re: How can small molecule degrade?

Postby 29yrsExperience » Sep 04 2018 6:16 pm

For a very general answer- heat and pH challenges also can cause proteins to degrade, and there is also the concept of half-life- proteins (and other molecules) tend to have limited lifespans due to entropy, ultimately. Some are more stable (longer half-life) than others. Enzymes, which are organic catalysts, speed up processes that would happen eventually anyway, just more slowly.
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Re: How can small molecule degrade?

Postby talkingtree » Sep 05 2018 12:36 am

Thanks for the reply. Sorry, I didn't clarify properly, small molecule = compound. I was using protein as an example. How can small molecules degrade?
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Re: How can small molecule degrade?

Postby r.rosati » Sep 06 2018 3:47 pm

Hi! Most small molecule drugs are metabolized in the liver by proteins of the Cytochrome P450 family. You could perhaps start by looking here and here.
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Re: How can small molecule degrade?

Postby talkingtree » Sep 07 2018 12:16 am

r.rosati wrote:Hi! Most small molecule drugs are metabolized in the liver by proteins of the Cytochrome P450 family. You could perhaps start by looking here and here.


Arrr ok, thanks
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